A change of circumstances or fortune, typically one that is unwelcome or unpleasant
her husband's sharp vicissitudes of fortune
Alternation between opposite or contrasting things
the vicissitude of the seasons
(vicissitude) a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
(vicissitude) mutability in life or nature (especially successive alternation from one condition to another)
(vicissitude) vi·cis·si·tude (vî-sîsąî-tˇd´, -tyˇd´) noun 1. a. A change or variation. b. The quality of being changeable; mutability. 2. Often vicissitudes. One of the sudden or unexpected changes or shifts often encountered in one's life, activities, or surroundings. ...
(vicissitude) (n.) event that occurs by chance (The vicissitudes of daily life prevent me from predicting what might happen from one day to the next.)
(vicissitude) a change of circumstances affecting one's life.
Rapid, unpredictable and often violent changes which completely alter the previously existing situation.
[viss-iss-it-yewds] Noun, pl changes in circumstance or fortune
a change or variation occurring in the course of something